C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/235 (2006.01) A61K 31/357 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4745 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2436770
The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of I.kappa.B kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and immune-related diseases or disorders, as demonstrated in vivo . Further embodiments of the present invention relate to a specific IKK inhibitors, 4(2'-aminoethyl)amino- 1,8- dimethylimidazo(1,2-a) quinoxaline and compounds of formula (I), salts thereof, and pharmaceutical compositions.
L'invention concerne des méthodes de prévention et de traitement de troubles ou de maladies d'origine immune et inflammatoires à l'aide d'inhibiteurs d'I.kappa.B kinase (IKK). L'invention concerne également des inhibiteurs IKK efficaces dans la prévention et le traitement de troubles ou de maladies d'origine immune et inflammatoires, comme démontré in vivo. D'autres modes de réalisation de l'invention concerne des inhibiteurs IKK spécifiques, 4(2'-aminoéthyl)amino- 1,8-diméthylimidazo(1,2-a) quinoxaline et des composés de formule (I), les sels de ces composés, ainsi que des compositions pharmaceutiques.
Burke James R.
Nadler Steven
Qiu Yuping
Townsend Robert M.
Zusi Fred Christopher
Bristol-Myers Souibb Company
Gowling Lafleur Henderson Llp
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