Methods of treating inflammatory bowel disease using cholera...

A - Human Necessities – 61 – K

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Details

A61K 38/16 (2006.01) A61P 1/00 (2006.01) A61P 7/06 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2391415

The present invention provides a method of treating or preventing inflammation in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. The present invention also provides a method of decreasing the activity of interferon gamma in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. Further provided is a method of decreasing the activity of IL-12 in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B. Additionally, the present invention provides a method of treating or preventing a Th1 T-cell mediated autoimmune disorder in a subject, comprising administering to the subject an effective amount of cholera toxin subunit B.

L'invention concerne une méthode de traitement ou de prévention d'une inflammation chez un sujet, qui consiste à administrer audit sujet une quantité effective d'une sous-unité B de la toxine du choléra. Elle concerne également une méthode qui permet de diminuer l'activité de l'interféron gamma chez un sujet, qui consiste à administrer audit sujet une quantité effective d'une sous-unité B de la toxine du choléra. L'invention concerne en outre une méthode qui permet de diminuer l'activité d'IL-12 chez un sujet, qui consiste à administrer audit sujet une quantité effective d'une sous-unité B de la toxine du choléra. Elle concerne enfin une méthode de traitement ou de prévention d'une maladie auto-immune induite la cellule Th1 chez un sujet, qui consiste à administrer audit sujet une quantité effective d'une sous-unité B de la toxine du choléra.

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