A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/175 (2006.01)
Patent
CA 2630148
The present invention relates to methods of treating or preventing ischemia- related (i.e., neural cell hypoxia and/or hypoglycemic) conditions by administering to a patient in need thereof certain thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing or treating certain ischemia-related conditions, which may include Alzheimer's disease, Parkinson's disease, and ischemic states that are due to or result from such conditions as: coronary artery bypass graft surgery; global cerebral ischemia due to cardiac arrest; focal cerebral infarction; cerebral hemorrhage; hemorrhage infarction; hypertensive hemorrhage; hemorrhage due to rupture of intracranial vascular abnormalities; subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms; hypertensive encephalopathy; carotid stenosis or occlusion leading to cerebral ischemia; cardiogenic thromboembolism; spinal stroke and spinal cord injury; diseases of cerebral blood vessels, e.g., atherosclerosis, vasculitis; macular degeneration; myocardial infarction; cardiac ischemia; and superaventicular tachyarrhytmia.
L'invention porte sur des méthodes de traitement ou de prévention de troubles associés à l'ischémie (c.-à-d. l'hypoxie des cellules nerveuses et/ou l'hypoglycémie) par administration à un patient le nécessitant de certains composés de thiosemicarbazone, et plus particulièrement sur des méthodes de traitement ou de prévention de troubles associés à l'ischémie pouvant comprendre la maladie d'Alzheimer, la maladie de Parkinson, et des troubles résultant de ces conditions tels que: les pontages des coronaires, l'ischémie cérébrale globale due à un arrêt cardiaque, l'infarctus cérébral focal, les hémorragies cérébrales, les infarctus hémorragiques, les hémorragies par hypertension, les hémorragies par rupture d'anomalies vasculaires intracrâniennes, les hémorragies subarachnoïdes par rupture d'anévrismes artériels intracrâniens, l'encéphalopathie hypertensive, la sténose des carotides ou l'occlusion conduisant à l'ischémie cérébrale, les thromboembolies cardiogènes, les traumatismes et atteintes médullaires, les maladies des vaisseaux cérébraux (dont l'athérosclérose, la vasculite), la dégénérescence maculaire, l'infarctus du myocarde, l'ischémie cardiaque, et la tachyarythmie supraventriculaire.
Almassian Bijan
Ghanbari Hossein A.
Jiang Zhi-Gang
Leibowitz Michael S.
Pan Weiying
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Panacea Pharmaceuticals Inc.
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