Methods of treating ischemic related conditions

Details Methods of treating ischemic related conditions Methods of treating ischemic related conditions

A - Human Necessities

61

K

A61K 31/44 (2006.01)

Patent

CA 2525298

The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of the present invention relates to methods of treating specific ischemia-related conditions, including but not limited to Alzheimer's disease, Parkinson's disease, Coronary artery bypass graft surgery, Global cerebral ischemia due to cardiac arrest, focal cerebral infarction, cerebral hemorrhage, hemorrhage infarction, hypertensive hemorrhage. hemorrhage due to rupture of intracranial vascular abnormalities, subarachnoid hemorrhage due to rupture of intracranial arterial aneurysms, hypertensive encephalopathy, carotid stenosis or occlusion leading to cerebral ischemia, cardiogenic thromboembolism, spinal stroke and spinal cord injury, diseases of cerebral blood vessels: e.g., atherosclerosis, vasculitis, Macular degeneration, myocardial infarction, cardiac ischemia and superaventicular tachyarrhytmia.

L'invention se rapporte à des procédés permettant de traiter des états liés à une ischémie, par administration de certains composés thiosémicarbazones à un patient nécessitant un tel traitement. Dans les modes de réalisation préférés, cette invention concerne des procédés permettant de traiter des états liés à une ischémie spécifique, parmi lesquels figurent, de manière non exhaustive : la maladie d'Alzheimer, la maladie de Parkinson, le pontage aortocoronarien par greffe, l'ischémie cérébrale globale due à un arrêt cardiaque, l'infarctus cérébral focal, l'hémorragie cérébrale, l'infarctus hémorragique, l'hémorragie hypertensive, l'hémorragie due à la rupture de malformations vasculaires intracrâniennes, l'hémorragie subarachnoïdienne due à la rupture d'anévrysmes artériens intracrâniens, l'encéphalopathie hypertensive, la sténose ou l'occlusion carotidienne entraînant une ischémie cérébrale, la thromboembolie cardiogène, l'infarctus médullaire et le traumatisme médullaire, ainsi que des maladies des vaisseaux sanguins cérébraux telles que l'athérosclérose, la vasculite, la dégénération maculaire, l'infarctus du myocarde, l'ischémie cardiaque et la tachyarythmie supraventriculaire.

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