A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) G01N 33/564 (2006.01) A61K 38/11 (2006.01)
Patent
CA 2391944
The invention provides methods identifying individuals suitable for treatment for lupus and methods of monitoring treatment, based on measuring antibody affinities, as well as of treating lupus based on measuring antibody affinities. The treatment entails administration of a conjugate comprising a non-immunogenic valency platform molecule and at least two double stranded DNA epitopes, such as DNA molecules, which bind to anti-DNA antibodies from the patient.
L'invention concerne des procédés permettant d'identifier des individus convenant pour le traitement du lupus ainsi que des procédés de surveillance du traitement, sur la base de la mesure des affinités aux anticorps. Le traitement implique l'administration d'un conjugué constitué d'une molécule à plate-forme de valences non-immunogène et au moins deux épitopes d'ADN à deux brins, par exemple des molécules d'ADN, qui se lient à des anticorps anti-ADN du patient.
Linnik Matthew D.
Mcneeley Patricia A.
Borden Ladner Gervais Llp
Lajolla Pharmaceutical Company
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