Methods of treating lupus using cd4 antibodies

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2645322

Methods of treating lupus, including systemic lupus erythematosus, cutaneous lupus erythmetosus, and lupus nephritis, are provided. The methods involve administration of a combination of a non-depleting CD4 antibody and another compound used clinically or experimentally to treat lupus. Methods of treating lupus nephritis by administration of a non-depleting CD4 antibody that results in an improvement in renal function and/or a reduction in proteinuria or active urinary sediment are also provided. Methods of treating multiple sclerosis by administration of a non-depleting CD4 antibody, optionally in combination with another compound used clinically or experimentally to treat MS, are described. Methods of treating transplant recipients and subjects with rheumatoid arthritis, asthma, psoriasis, Crohn's disease, ulcerative colitis, and Sjogren's syndrome are also provided.

L'invention a pour objet des procédés de traitement du lupus, y compris le lupus érythémateux disséminé, le lupus érythémateux cutané et la néphrite lupique. Les procédés comprennent l'administration d'une combinaison d'un anticorps CD4 non-déplétif et d'un autre composé de traitement du lupus à usage clinique ou expérimental. L'invention a également pour objet des procédés de traitement de la néphrite lupique par l'administration d'un anticorps CD4 non-déplétif produisant une amélioration de la fonction rénale et/ou une baisse de la protéinurie ou des sédiments urinaires actifs. Des procédés de traitement de la sclérose en plaques par l'administration d'un anticorps CD4 non-déplétif, éventuellement en combinaison avec un autre composé de traitement de la sclérose en plaques à usage clinique ou expérimental, sont également décrits. Enfin, l'invention a trait à des procédés de traitement de greffés et de sujets atteints d'arthrite rhumatoïde, d'asthme, de psoriasis, de la maladie de Crohn, de colite ulcérative et du syndrome de Sjögren.

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