Methods of treating mental diseases, inflammation and pain

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/365 (2006.01) A61K 31/35 (2006.01) A61K 31/366 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2274103

Methods are disclosed for treating or preventing disorders such as mental diseases, inflammation and pain by inhibiting the enzyme anandamide amidohydrolase. A therapeutically effective level of an anandamide amidohydrolase inhibitor is administered such as a therapeutically effective level of a haloenol lactone. Preferably, the haloenol lactone is of formula (I) wherein R is hydrogen, R1 is a halogen, and R2 is selected from the group consisting of aryl, aryloxy, and heteroaryl radicals, derivatives of said haloenol lactones, and mixtures thereof. The haloenol lactone, E-6-(bromomethylene)tetrahydro-3-(1- naphthalenyl}-2H-pyrane-2-one, is most preferred.

L'invention concerne des méthodes qui permettent de traiter ou de prévenir des troubles tels que les maladies mentales, l'inflammation et la douleur, en inhibant l'anandamide amidohydrolase. On administre une quantité thérapeutiquement efficace d'un inhibiteur de l'anandamide amidohydrolase, par exemple une quantité thérapeutiquement efficace d'une haloénol-lactone. De préférence, la haloénol-lactone correspond à la formule (I), dans laquelle R est l'hydrogène, R1 est un halogène et R2 est choisi dans le groupe comprenant les radicaux aryle, aryloxy et hétéroaryle, les dérivés desdites haloénol-lactones et leurs mélanges. La haloénol-lactone préférée est la E-6-(bromométhylène)tétrahydro-3-(1-naphtalényl)-2H-pyrane-2-one.

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