Methods of treating mental retardation, down's syndrome,...

Details Methods of treating mental retardation, down's syndrome,... Methods of treating mental retardation, down's syndrome,...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/428 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2670116

Subjects having at least one condition selected from the group consisting of mental retardation, Down's syndrome, fragile X syndrome and autism are treated with a composition that includes gamma-am inobutyric acid agonists and/or Ml muscarinic rreceptor antagonists. The gamma-am inobutyric acid agonist (GABA) can be a GABA(B) agonist, such as baclofen. GABA(B) agonists can be used in combination with Group I mGluR antagonists and Ml muscarinic receptor antagonists in methods of treating humans.

Selon l'invention, on traite des sujets présentant un état choisi dans le groupe composé du retard mental, du syndrome de Down, du syndrome de l'X fragile et de l'autisme au moyen d'une composition comprenant des agonistes de l'acide gamma-aminobutyrique et/ou des antagonistes du récepteur muscarinique MI. L'agoniste de l'acide gamma-aminobutyrique (GABA) peut être un agoniste GABA(B), tel que le baclofène. Les agonistes GABA(B) peuvent être utilisés en combinaison avec des antagonistes mGluR du groupe I et des antagonistes du récepteur muscarinique MI selon des procédés de traitement d'humains.

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