A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2343579
Antagonists of alpha4 integrin/alpha4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their alpha4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.
La présente invention concerne des antagonistes de l'adhésion intégrine alpha4/ligands de l'intégrine alpha4 qui inhibent les effets biologiques d'une telle adhésion, ainsi qu'une description des méthodes correspondantes. Ces antagonistes permettent d'empêcher la destruction osseuse associée au myélome multiple. On inhibe ainsi la migration des cellules myélomateuses vers la moelle osseuse et la libération intégrine-dépendante, par lesdites cellules, de facteurs de résorption osseuse qui conduisent à la destruction osseuse chez les patients atteints de myélome multiple.
Mundy Gregory R.
Yoneda Toshiyuki
Board Of Regents The University Of Texas System
Smart & Biggar
LandOfFree
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