A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/353 (2006.01) A61K 31/352 (2006.01) A61K 31/7048 (2006.01) A61P 21/00 (2006.01)
Patent
CA 2750761
The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav- 4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2', 3', 4', 5', or 6' modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2', 3', 4', 5', or 6' modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.
La présente invention concerne des procédés visant à traiter la dystrophie musculaire de Duchenne avec des flavonoïdes. Lesdits procédés peuvent consister à (a) se procurer une composition pharmaceutique comprenant une quantité thérapeutiquement efficace d'un flavonoïde, et (b) administrer la composition à un patient humain, le flavonoïde comprenant une isoflav-4-one avec l'un au moins des carbones aux positions 8, 7, 6, 5, 2, 2', 3', 4', 5' et 6' modifié par un groupe alcool. En variante, le flavonoïde peut comprendre (1) un flavan-3-ol avec l'un au moins des carbones aux positions 8, 7, 6, 5, 4, 2', 3', 4', 5' et 6' modifié par un groupe alcool, ou (2) une flavone à cycle B libre avec l'un au moins des carbones aux positions 8, 7, 6, 5 et 3 modifié par un groupe alcool et l'un au moins des carbones aux positions 8, 7, 6, 5 et 3 modifié par un groupe glycoside.
Bitto Alessandra
Burnett Bruce P.
Messina Sonia
Squadrito Francesco
Vita Giuseppe
Primus Pharmaceuticals Inc.
Ridout & Maybee Llp
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