A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 38/49 (2006.01) A61P 25/28 (2006.01) G01N 33/50 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2511294
The present invention relates to a method of treating neurological conditions in a mammal by administering a hematopoietic growth factor such as granulocyte- colony stimulating factor (GCSF) and granulocyte-macrophage colony stimulating factor (GMCSF). The invention also provides methods of screening for compounds that bind to a GCSF or GMCSF receptor found on the surface of a neuronal cell; and which provides a neuroprotective, neuroproliferative and/or a STAT gene activation activity.
Cette invention concerne une méthode de traitement d'états neurologiques chez un mammifère, laquelle méthode consiste à administrer un facteur de croissance hématopoïétique tel que le facteur de stimulation des granulocytes (GCSF) et le facteur de stimulation des granulocytes et macrophages (GMCSF). Cette invention concerne également des méthodes de criblage de composés qui se lient à un récepteur du facteur GCSF ou GMCSF présent sur la surface d'une cellule neuronale et qui produisent un effet neuroprotecteur, de neuroprolifération et/ou d'activation du gène STAT.
Gassler Nikolaus
Kollmar Rainer
Krueger Carola
Maurer Martin
Schaebitz Wolf-Ruediger
Axaron Bioscience Ag
Goudreau Gage Dubuc
Sygnis Bioscience Gmbh & Co. Kg
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