Methods of treating or preventing cardiac arrhythmia

Details Methods of treating or preventing cardiac arrhythmia Methods of treating or preventing cardiac arrhythmia

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/00 (2006.01) A61K 31/50 (2006.01) C07F 9/53 (2006.01)

Patent

CA 2268942

This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly- activating delayed rectifier K+ current (IKur) of the human atrium in a use- dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.

L'invention concerne une méthode de traitement et de prévention d'arythmies cardiaques dans laquelle on utilise des composés qui sont des inhibiteurs du courant redresseur retardé K<+> (IKur) d'activation ultra-rapide de l'oreillette humaine en fonction de l'utilisation et de la vitesse et qui produit le bloc sélectif de préférence à des rythmes cardiaques rapides de sorte que l'effet soit produit ou maximisé lorsque c'est nécessaire.

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