Methods of treating or preventing interstitial cystitis

Details Methods of treating or preventing interstitial cystitis Methods of treating or preventing interstitial cystitis

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/535 (2006.01) C07D 209/14 (2006.01) C07D 209/16 (2006.01)

Patent

CA 2247822

This invention provides methods for the treatment or prevention of interstitial cystitis or urethral syndrome in a mammal which comprise administering to a mammal in need thereof an effective amount of a compound of formula (I), where R1 and R2 are independently selected from the group consisting of hydrogen, methyl, methoxy, chloro, and trifluoromethyl, with the proviso that no more than one of R1 and R2 can be hydrogen; and Y is (1), (2), (3), (4), (5), (6), N-Ra, or CH-NRbRc, where Ra, Rb, and Rc are independently selected from the group consisting of hydrogen and C1-C6 alkyl; or a pharmaceutically acceptable salt or solvate thereof.

L'invention concerne des méthodes de traitement ou de prévention de la cystite interstitielle ou le syndrome urétral chez un mammifère. Ces méthodes consistent à administrer à un mammifère une dose efficace d'un composé présentant la formule (I) dans laquelle R¿1? et R¿2? sont indépendamment sélectionnés dans le groupe constitué par hydrogène, méthyle, méthoxy, chloro et trifluorométhyle, à condition qu'un seul élément entre R¿1? et R¿2? puisse représenter hydrogène; et Y est égal à (1), (2), (3), (4), (5), (6), N-R?a¿, ou CH-NR?b¿R?c¿ où R?a¿, R?b¿ et R?c¿ sont indépendamment sélectionnés dans le groupe constitué par hydrogène et alkyle C¿1?-C¿6?; ou un sel ou un solvate pharmaceutiquement acceptables de ces derniers.

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