A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/32 (2006.01) A61K 38/16 (2006.01)
Patent
CA 2636187
A method of treating or preventing tissue damage occurring subsequent to affecting an increase in blood flow through a blood vessel which is in communication with the tissue, by administering an effective amount of a composition including a tissue damage-reducing or -preventing polypeptide including at least one of Thymosin beta 4 (T~4), an isoform of T~4, an N- terminal fragment of T~4, a C-terminal fragment of T~4, T~4 sulfoxide, an LKKTET peptide, an LKKTNT peptide, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization- modulating peptide, or a conservative variant thereof having tissue damage- reducing activity. The composition is administered to the tissue before, during and/or after affecting the increase in blood flow.
La présente invention concerne un procédé de traitement de tissus endommagés ou de prévention de leur endommagement suite à l~affectation d~une augmentation du débit sanguin par le biais d~un vaisseau sanguin en communication avec le tissu, en administrant une quantité effective de composition comprenant une réduction d~endommagement de tissus ou un polypeptide de prévention comprenant au moins un peptide thymosine bêta 4 (Tß4), un isoforme de Tß4, un fragment de terminal N de Tß4, un fragment de terminal C de Tß4, du sulfoxyde Tß4, un peptide LKKTET, un peptide LKKTNT, un peptide séquestrant d~actine, un peptide de liaison d~actine, un peptide de mobilisation d~actine, un peptide de modulation de polymérisation d~actine ou encore une variante conservatrice de ces éléments à activité de réduction de l~endommagement de tissus. La composition est administrée aux tissus avant, pendant et/ou après affectation de l~augmentation du débit sanguin.
Finkelstein J.j.
Goldstein Allan L.
Blake Cassels & Graydon Llp
Regenerx Biopharmaceuticals Inc.
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