Methods of treating p38 kinase-associated conditions and...

Details Methods of treating p38 kinase-associated conditions and... Methods of treating p38 kinase-associated conditions and...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 29/00 (2006.01) C07D 209/00 (2006.01) C07D 253/00 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2429628

Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups ZR4R5 taken together comprise an NH-subsituted aryl.

L'invention porte sur une méthode permettant de traiter une ou plusieurs pathologies liées à l'activité de la kinase p38. Cette méthode consiste à administrer à un patient au moins un composé représenté par la formule (I), ou un sel acceptable d'un point de vue pharmaceutique, un promédicament, ou un solvate de ce composé. Dans ladite formule, R¿3? représente un hydrogène, un méthyle, un perfluorométhyle, un méthoxy, un halogène, un cyano, ou un groupe NH¿2?, de préférence un méthyle, et X, R¿1? à R¿6?, et Z correspondant à la définition donnée dans la description. Les groupes ZR¿4?R¿5? offrent l'avantage, lorsqu'ils sont réunis, de contenir un groupe aryle substitué par -NH.

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