C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/08 (2006.01) A61K 31/135 (2006.01) A61K 31/4468 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01) C07D 489/04 (2006.01)
Patent
CA 2592407
The present invention is directed to methods and compositions for inducing, promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management of vertebrate animals including humans, for the prevention or alleviation of pain, particularly moderate to severe pain. In particular, the nitric oxide donor is a slow-release nitric oxide donor or is formulated to provide a sustained release of a low dose of nitric oxide.
La présente invention concerne des procédés et des compositions visant à induire, à favoriser ou à faciliter le soulagement de la douleur. Plus particulièrement, cette invention décrit l~association composée d~un donneur de monoxyde d~azote et d~un analgésique opioïde dans la prise en charge thérapeutique d~animaux vertébrés, y compris les humains, pour la prévention ou le soulagement de la douleur, en particulier la douleur modérée à sévère. En particulier, le donneur de monoxyde d~azote est un donneur de monoxyde d~azote à libération retardée ou est formulé de façon à assurer une libération prolongée d~une faible dose de monoxyde d~azote.
Smith Maree Therese
Williams Craig Mckenzie
Fetherstonhaugh & Co.
The University Of Queensland
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