Methods of treating pain and inflammation in neuronal tissue...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 17/02 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2636288

Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.

La présente invention concerne l'utilisation d'antagonistes de l'IL-31 pour traiter l'inflammation et la douleur en inhibant, prévenant, réduisant, limitant ou réduisant au minimum la stimulation dans tissus neuronaux. Lesdits antagonistes incluent des anticorps ainsi que des fragments, dérivés ou variantes de ceux-ci. Les antagonistes selon l'invention permettent d'atténuer des symptômes tels que douleur, picotements, sensibilisation et picotements associés aux neuropathies.

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