Methods of treating psychosis and schizophrenia based on...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C12N 15/12 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2742074

The present application is directed to the use of genetic polymorphism in the ErbB4 gene to predict whether a patient is likely to respond to psychotic medication Paliperidone. The polymorphism in the ErbB4 gene is also used to predict whether a patient is likely to display placebo effect among patients in need of psychotic treatment. A method of treating patients with antipsychotic medication Paliperidone using the polymorphism in the ErbB4 gene and a kit of are also provided.

La présente invention concerne l'utilisation du polymorphisme génétique dans le gène ErbB4 pour prédire si un patient est susceptible de répondre au médicament antipsychotique palipéridone. Le polymorphisme dans le gène ErbB4 est également utilisé pour prédire si un patient est susceptible de présenter un effet placebo parmi des patients nécessitant un traitement antipsychotique. La présente invention concerne en outre un procédé de traitement de patients avec le médicament antipsychotique palipéridone en utilisant le polymorphisme dans le gène ErbB4 et une trousse.

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