Methods of treating, reducing and inhibiting the appearance...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/37 (2006.01) A61K 8/96 (2006.01) A61Q 7/00 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2644664

Methods of treating, reducing and inhibiting the appearance of ageing in the skin are provided. Also provided are uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subject comprising applying a granzyme B inhibitor to the skin of the subject. Also provided are methods of identifying a granzyme B inhibitors and agonists.

Cette invention concerne des méthodes visant à traiter, à réduire et à inhiber l'aspect de vieillissement de la peau. Cette invention concerne également des utilisations et des méthodes permettant de conserver un aspect jeune, de réduire l'aspect de vieillissement, d'inhiber l'aspect de vieillissement, de réduire la vitesse de vieillissement, de réduire l'inélasticité de la peau, de réduire la vitesse d'augmentation de l'inélasticité de la peau, de conserver l'élasticité de la peau et d'accroître la densité des follicules pileux de la peau d'un sujet, lesquelles méthodes consistent à appliquer un inhibiteur de granzyme B sur la peau du sujet. Cette invention concerne également des méthodes d'identification d'inhibiteurs et d'agonistes de granzyme B.

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