Methods of treating rsv infections and related conditions

Details Methods of treating rsv infections and related conditions Methods of treating rsv infections and related conditions

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2688667

The present invention provides methods for managing, treating and/or ameliorating a respiratory syncytial virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), and/or a symptom or a long-term respiratory condition relating thereto (e.g., asthma, wheezing, reactive airway disease (RAD), or chronic obstructive pulmonary disease (COPD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity and further comprise a modified IgG constant domain, or FcRn-binding fragment thereof, to not only decrease RSV infection, but also decrease the pro-inflammatory epithelial cell immune responses in order to mitigate the later development of asthma and/or wheezing and/or COPD in said patient.

L'invention concerne des procédés pour gérer, traiter et/ou améliorer une infection par le virus respiratoire syncytial (VRS) (par exemple, la crise aiguë de VRS ou une infection des voies respiratoires supérieures (IVRS) par le VRS et/ou une infection des voies respiratoires inférieures (IVRI)), et/ou un symptôme ou un état respiratoire chronique associé (par exemple l'asthme, le cornage, la maladie respiratoire réactive (RAD) ou la bronchopneumopathie chronique obstructive (BPCO)) chez un sujet, comprenant l'administration audit être humain d'une quantité efficace d'un ou plusieurs anticorps qui se lient de manière immunospécifique à un ou plusieurs antigènes du VRS avec une affinité élevée et/ou une avidité élevée, et qui comprennent en outre un domaine constant IgG modifié ou un fragment de liaison FcRn de celui-ci, pour faire décroître, non seulement l'infection par le VRS mais aussi les réponses immunitaires des cellules épithéliales pro-inflammatoires afin de modérer le développement ultérieur d'asthme et/ou de cornage et/ou d'une bronchopneumopathie chronique obstructive chez le patient.

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