A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/27 (2006.01) A61P 19/00 (2006.01)
Patent
CA 2390632
The invention relates to methods and articles of manufacture for treating short stature disorders related to the Short Stature Homeobox-containing (SHOX) gene which, in the human genome, is located in the pseudoautosomal region (PAR1) on the short arm of the X chromosome (Xp22.3) and Y chromosome (Yp11.3). More particularly, the invention relates to methods for treating a SHOX gene disorder, other than Turner syndrome, due to deficiency of one copy (haploinsufficiency) of the SHOX gene, by administering a growth hormone, particularly by administering human growth hormone to a human subject with a SHOX gene disorder.
L'invention concerne des procédés et des produits fabriqués pour traiter les troubles de la petite taille liés au gène contenant l'homéoboîte de la petite taille (gène SHOX) qui, dans le génome humain, se situe dans la zone pseudoautosomale (PAR1) sur le bras court du chromosome X (Xp22,3) et du chromosome Y (Yp11,3). Plus particulièrement, l'invention concerne des procédés de traitement d'un trouble des gènes SHOX, autre que le syndrome de Turner, dû à une déficience d'une copie (haploinsuffisance) du gène SHOX. Ces procédés consistent à administrer une hormone de croissance, et plus particulièrement, à administrer une hormone de croissance humaine à un sujet humain souffrant d'un trouble des gènes SHOX.
Rao Ercole
Rappold-Hoerbrand Gudrun
Rappold-Hoerbrand Gudrun
Torys Llp
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