A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/34 (2006.01) A61K 9/70 (2006.01) A61K 31/50 (2006.01) A61K 31/502 (2006.01) A61K 31/7048 (2006.01) A61K 38/44 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2678256
The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an antioxidant, a compound to treat cardiovascular diseases, a nitrosated compound, a compound that donates, transfers or relases NO, or is a NO synthase substrate, or endogenously stimulates NO synthesis, or stimulates levels of endothelium derived relaxing factor. In the said composition, a hydralazine compound may be an antioxidant, isosorbide mono-or dinitrate may be the compound to donate, transfer, release, or stimulate endogenous NO synthesis. The isorsorbide may also elevate endogenous levels of endotherlium-derived relaxing factor, or be a NO synthase substrate and angiotensin enzyme inhibitor may be nitrosated compound. Disclosed in the invention is also a method to treat, or prevent Renaud's syndrome by administering a therapeutically effective amount of an antioxidant, a NO donor, a nitrosated compound and novel sustained-release formulations (e.g. a transdermal patch, See Figure 2).
Loberg Michael D.
Loscalzo Joseph
Vita Joseph A.
Worcel Manuel
Bennett Jones Llp
Nitromed Inc.
Trustees Of Boston University
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