Methods of treatment employing prolonged continuous infusion...

Details Methods of treatment employing prolonged continuous infusion... Methods of treatment employing prolonged continuous infusion...

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 47/18 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2717207

The present invention relates generally to the treatment of diseases and disorders that are mediated by histone deacetylase (HDAC), for example, cancer, with Belinostat' (also known as (E)-N- hydroxy-3-(3-phenylsulfamoyl-phenyl)-acry- lamide; PXD101; and PX 105684), and more particularly, to improvement treatments of such diseases (for example, cancers, for example, leukemias), which employ prolonged continuous infusion (e.g., prolonged continuous intravenous infusion) of Belinostat.TM..

La présente invention porte d'une manière générale sur le traitement de maladies et de troubles qui sont à médiation par l'histone désacétylase (HDAC), par exemple le cancer, par le BelinostatTM (également connu sous le nom de (E)-N-hydroxy-3-(3-phénylsulfamoyl-phényl)-acrylamide ; PXD101 ; et PX105684), et, plus particulièrement, sur des traitements d'amélioration de maladies (comme les cancers et, par exemple, les leucémies) qui emploient une perfusion continue prolongée (par exemple, une perfusion intraveineuse continue prolongée) de BelinostatTM.

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