A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/20 (2006.01)
Patent
CA 2429769
The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed to methods for treating a subject with an angiogenesis-related disease. In one embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA- 7 protein under the control of a promoter operable in eukaryotic cells, is administered to said patient with a angiogenesis-related disease. The present invention thus provides for treatment of angiogenesis-related disease by through expression of mda-7 and inhibition angiogenesis. Such diseases include cancer.
L'invention concerne des procédés de thérapie génique servant à traiter des maladies humaines. Elle concerne, plus particulièrement, des procédés servant à traiter un individu atteint d'une maladie apparentée à l'angiogénèse. Dans un mode de réalisation, on administre à cet individu atteint d'une maladie apparentée à l'angiogénèse un produit génétique d'expression adénovirale contenant un acide nucléique codant une protéine humaine MDA-7 sous le contrôle d'un promoteur opérationnel dans des cellules eucaryotes. Elle concerne, de ce fait, le traitement d'une maladie apparentée à l'angiogénèse au moyen de l'expression directe de MD-7 et de l'inhibition de l'angiogénèse. Ces maladies incluent le cancer.
Chada Sunil
Grimm Elizabeth
Mhashilkar Abner
Rajagopal Ramesh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
Introgen Therapeutics Inc.
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