C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2420499
The present invention relates to DNA vaccines useful for the prevention and treatment of ongoing autoimmune diseases. The compositions and methods of the invention feature the CpG oligonucleotide, preferably in a motif flanked by two 5' purines and two 3' pyrimidines. The vaccine may further comprise DNA encoding a specific antigen, or the peptide antigen itself. The invention is exemplified for IDDM.
L'invention concerne des vaccins ADN utiles dans la prévention et le traitement de maladies auto-immunes persistantes. Les compositions et les procédés de l'invention caractérisent l'oligonucléotide CpG, de préférence, dans un motif flanqué par deux purines 5' et deux pyrimidines 3'. Le vaccin peut, en outre, comprendre un ADN codant un antigène spécifique, ou un antigène de peptide lui-même. Une des applications de l'invention est le diabète insulino-dépendant.
Cohen Irun R.
Quintana Francisco J.
Ltd. Yeda Research And Development Co.
Ridout & Maybee Llp
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