Methods of treatment using ammonia-scavenging drugs

A - Human Necessities – 61 – K

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Details

A61K 31/216 (2006.01) A61P 13/00 (2006.01) G01N 33/48 (2006.01)

Patent

CA 2735218

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.

L'invention porte sur un procédé pour déterminer une dose et un programme et pour effectuer des ajustements de dose de promédicaments PBA utilisés pour traiter des états de rétention d'azote, ou des troubles d'accumulation d'ammoniac, par la mesure de l'excrétion urinaire de phénylacétylglutamine et/ou d'azote urinaire total. L'invention porte sur des procédés pour sélectionner un dosage approprié d'un promédicament PBA sur la base de labsorption de protéines alimentaires du patient, ou sur la base de traitements précédents administrés au patient. Les procédés sont applicables pour sélectionner ou modifier un régime de dosage pour un patient recevant un médicament désactivant l'ammoniac administré par voie orale.

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