Methods of treatment using mao-a and mao-b inhibitors such...

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/138 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01)

Patent

CA 2319318

Effects of MAO-A or MAO-B inhibitors such as L-deprenyl on both cerebral and peripheral vasculature, on non-vascular smooth muscle, on the nervous system, and on platelets, RBC, WBC, mast cells, macrophages, and glial cells are disclosed. The effects are the result of a mode of action for MAO-A or MAO-B inhibitors such as L-deprenyl which is totally unrelated to selective inhibition of MAO-A and/or MAO-B. Therapeutic methods of using MAO-A or MAO-B inhibitors such as L-deprenyl to treat a variety of disorders are disclosed.

L'invention porte sur les effets des inhibiteurs MAO-A et MAO-B tels que L-déprényl sur le système vasculaire cérébral et périphérique, sur les muscles lisses vasculaires, sur le système nerveux et sur les plaquettes sanguines, les effets sur les hématies, les effets sur les leucocytes, les mastocytes, les macrophages et les cellules gliales. Les effets sont le résultat d'un mode d'action des inhibiteurs MAO-A et MAO-B tels que L-déprényl qui n'a aucun rapport avec l'inhibition sélective de MAO-A ou MAO-B. L'invention porte également sur des procédés thérapeutiques d'utilisation des inhibiteurs MAO-A ou MAO-B tels que L-déprényl pour traiter une diversité de troubles.

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