A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 37/06 (2006.01) G01N 33/15 (2006.01) G01N 33/53 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2725154
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibod-ies, that specifically bind to the human interleukin-21 receptor (IL- 21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in partic-ular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R- associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
Linvention concerne des protéines de liaison et des fragments de liaison à un antigène de celles-ci, y compris des anticorps humains, qui se lient spécifiquement au récepteur dinterleukine-21 humain (IL-21R) et des procédés pour les utiliser. Les protéines de liaison peuvent agir, par exemple, comme des antagonistes de lactivité dIL-21R, modulant ainsi les réponses immunitaires en général, et celles véhiculées par IL-21R en particulier. Les compositions et procédés divulgués peuvent être utilisés, par exemple, dans le diagnostic, le traitement et/ou la prévention de troubles associés à IL-21R, par exemple des troubles inflammatoires, des maladies auto-immunitaires, des allergies, le rejet de greffe ou dautres troubles du système immunitaire.
Adkins Karissa K.
Arai Maya
Bloom Laird
Gill Davinder
Guay Heath M.
Torys Llp
Wyeth Llc
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