Methods of treatment utilizing certain melatonin derivatives

A - Human Necessities – 61 – K

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A61K 31/4045 (2006.01) A61P 3/04 (2006.01) A61P 25/06 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2601794

A method for treating anxiety disorders, affective disorders, obesity, intracranial injury, spinal cord injury, neurodegenerative diseases, sclerosis, migraine, fibromyalgia and cerebrovascular disease, using melatonin derivatives is disclosed. A specific melatonin derivative for use in the disclosed process is &bgr;-methyl-6-chloromelatonin (otherwise referred to as (R) -N- [2- (S-chloro-B-methoxy-lH-indol-S-yl) propyl] acetamide) .

L'invention concerne une méthode de traitement de troubles anxieux, de troubles affectifs, de lésions intracrâniennes, de lésions de la moelle épinière, de maladies neurodégénératives, de la sclérose, de la migraine, de la fibromyalgie et de maladies cérébrovasculaires, au moyen de dérivés de mélatonine. Un dérivé de mélatonine spécifique destiné à être utilisé dans le processus décrit est la ß-méthyl-6-chloromélatonine (également appelée (R)-N-[2-(6-chloro-5-méthoxy-1H-indol-3-yl)propyl]acétamide).

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