A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/19 (2006.01) A61K 31/203 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 31/35 (2006.01) A61K 31/353 (2006.01)
Patent
CA 2241758
Retinoid compounds which act specifically or selectively on RAR.alpha. receptor subtypes in preference over RAR.beta. and RAR.GAMMA. receptor subtypes, possess desirable pharmaceutical properties associated with retinoids, and are particularly suitable for treatment of tumors, such as acute monocytic leukemia, cervical carcinoma, myeloma, ovarian carcinomas and head and neck carcinomas, without having one or more undesirable side effects of retinoids, such as inducement of weight loss, mucocutaneous toxicity, skin irritation and teratogenicity.
L'invention concerne des composés rétinoïdes agissant spécifiquement ou sélectivement sur des sous-types de récepteurs RAR¿.alpha.?, de préférence sur des sous-types des récepteurs RAR¿.beta.? et RAR¿.GAMMA.?. Ils possèdent les propriétés pharmaceutiques souhaitables associées aux rétinoïdes, et sont notamment appropriés pour le traitement de tumeurs, telles que la leucémie monocytaire aiguë, le carcinome du col utérin, le myélome, les carcinomes ovariens et les carcinomes de la tête du col, sans présenter un ou plusieurs des effets secondaires indésirables des rétinoïdes, tels que l'induction d'un amaigrissement, la toxicité mucocutanée, l'irritation cutanée et la tératogénicité.
Chandraratna Roshantha A.
Duong Tien T.
Teng Min
Allergan Inc.
Gowling Lafleur Henderson Llp
Vision Pharmaceuticals L.p.
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