A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/555 (2006.01) A61K 31/395 (2006.01) A61K 31/409 (2006.01) A61K 31/4439 (2006.01) A61P 9/00 (2006.01) A61P 25/16 (2006.01)
Patent
CA 2189528
The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite.
Procédé de traitement de maladies par la décomposition de peroxynitrite, de préférence en produits bénins, qui consiste à utiliser un complexe qui est une structure de ligand sélectionnée fournissant un complexe métallique tel que des métaux de transition de Mn, Fe, Ni et V. Le procédé d'utilisation, ainsi que les nouvelles compositions pharmaceutiques à cet effet, sont destinés au traitement de maladies avantageusement combattues par la décomposition de peroxynitrite à un rythme supérieur au rythme naturel fondamental de décomposition du peroxynitrite chez des humains souffrant desdites maladies. Ledit procédé consiste à administrer une quantité d'un complexe, sous forme d'unité dosée, qui est efficace pour accélérer la décomposition du peroxynitrite.
Salvemini Daniela
Stern Michael Keith
Monsanto Company
Osler Hoskin & Harcourt Llp
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