Methods of use of uncoated gel particles

Details Methods of use of uncoated gel particles Methods of use of uncoated gel particles

C - Chemistry, Metallurgy

12

N

C12N 11/04 (2006.01) A61K 9/00 (2006.01) A61K 9/66 (2006.01) A61K 35/12 (2006.01) A61K 35/39 (2006.01) A61K 35/66 (2006.01) A61K 35/74 (2006.01) A61K 38/30 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C12N 5/00 (2006.01) C12N 5/04 (2006.01) C12N 5/10 (2006.01) A61K 35/30 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2187526

The invention covers a method of implanting a living donor cell into a host animal without inflammatory response or rejection of the donor cell by the host animal, by obtaining an uncoated particle of a biocompatible, temperature-independent gel that encapsulates the living donor cell, wherein the uncoated particle provides a molecular weight cutoff that prevents host animal immune cells from entering the particle, yet does not have to prevent entry of host animal IgG and complement into the particle, and implanting the uncoated particle into the host animal.

Procédé d'implantation d'une cellule donneuse vivante chez un animal hôte ne produisant pas de réaction inflammatoire ou de rejet de la cellule donneuse par l'animal hôte. Ce procédé consiste à produire une particule non enrobée formée d'un gel biocompatible ne dépendant pas de la température qui encapsule la cellule donneuse vivante, cette particule non enrobée produisant une masse molaire limite qui empêche les cellules immunes de l'animal hôte d'entrer dans la particule mais n'empêche pas l'IgG et les substances complémentaires d'entrer dans ladite particule; puis à implanter la particule non enrobée chez l'animal hôte.

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