A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4375 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2620915
Methods of treating, preventing or managing cancer, including certain leukernias are disclosed. The methods encompass the administration of enantiomerically pure (+)-l,4- dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-l- pyrrolidinyl]-4-oxo-l-(2-thiazolyl)-l,8- naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
L'invention porte sur des méthodes de traitement, prévention et gestion des cancers dont certaines leucémies consistant à administrer de l'acide (+)-1,4-dihydro-7-[(3s,4s)-3-méthoxy-4-(méthylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylique énantiomèrement pur et sur des méthodes de traitement utilisant ce composé en association avec la chimiothérapie, la radiothérapie, l'hormonothérapie, des thérapies biologiques ou l'immunothérapie. L'invention porte également sur des préparations pharmaceutiques et des formes posologiques unitaires utilisables dans lesdites méthodes.
Adelman Daniel C.
Arkin Michelle
Hyde Jennifer
Silverman Jeffrey A.
Walker Duncan
Osler Hoskin & Harcourt Llp
Sunesis Pharmaceuticals Inc.
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