Methods of using a hyaluronan receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2445627

Methods of using HARE protein or peptide fragments containing at least one of a HA-, a chondroitin- and a chondroitin sulfate-binding domain and monoclonal antibodies raised against HARE that block binding of at least one of HA, chondroitin and chondroitin sulfate thereto. Methods include targeting a compound to a cell expressing HARE or a cell that does not express a functionality active HARE, preventing interaction between a cell expressing HARE and a cell having at least one of a HA coat, a chondroitin coat and a chondroitin sulfate coat, and detecting at least one of HA, chondroitin and chondroitin sulfate in a sample.

La présente invention concerne des procédés permettant d'utiliser la protéine HARE ou des fragments peptides contenant l'un des domaines se liant au Ha, à la chondroïtine ou au sulfate de chondroïtine, et des anticorps monoclonaux dirigés contre de HARE qui bloquent la liaison de l'un au moins des HA, chondroïtine ou sulfate de chondroïtine. Ces procédés impliquent le ciblage d'un composé sur une cellule exprimant le HARE ou une cellule qui n'exprime pas un HARE fonctionnellement actif, puis la prévention de l'interaction entre une cellule exprimant le HARE et une cellule disposant de l'un au moins d'une gaine de HA, d'une gaine de chondroïtine ou d'une gaine de sulfate de chondroïtine, et enfin de détecter l'un au moins des HA, chondroïtine et sulfate de chondroïtine dans un échantillon.

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