C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/35 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2386854
The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
La présente invention concerne d'une façon générale des séquences d'acides nucléiques et d'acides aminés d'un polypeptide de fusion comprenant un polypeptide de mycobacterium tuberculosis. L'invention concerne également un polypeptide hétérologue particulier, des vecteurs d'expression et des cellules hôtes comprenant de tels acides nucléiques. L'invention concerne enfin des procédés de production de tels polypeptides de fusion. L'invention concerne plus particulièrement des matériaux et des procédés permettant d'utiliser une telle séquence de M. tuberculosis comme partenaires de fusion pour favoriser une expression stable et à bon rendement de polypeptides hétérologues de recombinaison, qu'ils soient d'origine eucaryote ou procaryote.
Guderian Jeffrey
Skeiky Yasir
Corixa Corporation
Fetherstonhaugh & Co.
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