Methods of using agents that modulate bone formation and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 31/00 (2006.01) G01N 33/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2419152

The present invention is based on the discovery that overexpression of .DELTA.FosB leads to bone formation and that .DELTA.FosB expression inhibits adipogenesis. The present invention provides methods of identifying agents that modulate bone formation and adipogenesis. Moreover, the present invention provides methods for identifying genes that are modulated by .DELTA.FosB, osteogenesis, and adipogenesis.

La présente invention est fondée sur la découverte que la surexpression de .DELTA.FosB produit une formation osseuse et que l'expression de .DELTA.FosB inhibe l'adipogenèse. Cette invention concerne des procédés permettant d'identifier des agents qui modulent la formation osseuse et l'adipogenèse, ainsi que des procédés qui permettent d'identifier des gènes qui sont modulés par .DELTA.FosB, l'ostéogenèse et l'adipogenèse.

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