Methods of using and compositions comprising...

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C - Chemistry, Metallurgy

07

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C07D 209/44 (2006.01) A61K 31/24 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) C07C 229/34 (2006.01) C07C 233/47 (2006.01) C07D 209/46 (2006.01)

Patent

CA 2506232

Enantiomerically pure (+)-3 -(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3- dihydro~isoindol-2-yl)-propionamide, and prodrugs, metabolites, polymorphs, salts, solvates (e.g., hydrates), and clathrates thereof are discussed. Methods of treating and/or preventing various diseases and disorders, such as those ameliorated by the reduction of levels of TNF-.alpha. or the inhibition of PDE4, are also disclosed.

L'invention concerne un (+)-3-(3,4-diméthoxy-phényl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide pur sur le plan énantiomère ainsi que des promédicaments, des métabolites, des polymorphes, des sels, des solvates et des clathrates de ce dernier. L'invention concerne également des méthodes permettant de traiter et/ou de prévenir des maladies et des troubles, tels que ceux améliorés par la réduction des taux de TNF-.alpha. ou l'inhibition de PDE4.

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