A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/397 (2006.01)
Patent
CA 2563377
Methods of treating, preventing and managing pulmonary hypertension are disclosed. Specific methods encompass the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate (e.g., hydrate), stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, surgery and/or lung transplantation. Specific second active agents are capable of reducing pulmonary artery pressure. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
L'invention concerne des procédés de traitement, de prévention et de gestion de l'hypertension pulmonaire. Des procédés spécifiques englobent l'administration d'un modulateur de PDE4, ou un sel, un solvate (par exemple un hydrate), un stéréomère, un clathrate ou un promédicament pharmaceutiquement acceptable de celui-ci, seul ou en combinaison avec un second agent actif, la chirurgie et/ou une greffe de poumons. De seconds agents actifs spécifiques peuvent réduire la pression artérielle pulmonaire. L'invention concerne également des compositions pharmaceutiques, des formes de dosage unitaires et des trousses destinées à être utilisées dans ces procédés.
Celgene Corporation
Smart & Biggar
LandOfFree
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