C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2653848
Uses for ant i- thymocyte globulin (ATG, e.g., Thymoglobulin®) and related compositions are described. In one aspect, ATG and, optionally, TGF-beta are used for in vitro generation of regulatory T cells, which are useful for cell therapy of immune-mediated conditions. In another aspect, ATG is directly administered to a subject at a low dose (e.g., less than 1 mg/kg per day) to treat an immune-mediated condition. The immune-mediated conditions include, for example, transplant rejection, graft-versus-host disease, and autoimmune diseases.
La présente invention concerne de nouvelles utilisations de la globuline anti-thymocyte (ATG, par exemple, Thymoglobulin®) et des compositions associées. Dans un aspect, l'ATG et, éventuellement, le facteur de croissance transformant .beta. (TGF-.beta.) sont utilisés pour la génération in vitro de lymphocytes T régulateurs, qui se révèlent utiles en thérapie cellulaire de pathologies immunitaires. Dans un autre aspect, l'ATG est administrée directement à un sujet, à faible dose (par exemple, moins de 1 mg/kg par jour), en vue de traiter une pathologie immunitaire. Lesdites pathologies immunitaires incluent notamment le rejet de greffe, la maladie du greffon contre l'hôte et des maladies autoimmunes.
Kaplan Johanne
Mcpherson John M.
Najafian Nader
Ruzek Melanie
Sayegh Mohamed H.
Genzyme Corporation
Mbm Intellectual Property Law Llp
The Brigham And Women's Hospital Inc.
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