Methods of using flt3-ligand in immunization protocols

Details Methods of using flt3-ligand in immunization protocols Methods of using flt3-ligand in immunization protocols

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/39 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2480128

The present invention relates to methods of using Flt3-ligand (Flt3-L) in immunization protocols to enhance immune responses against vaccine antigens. Embodiments include administering Flt3-ligand prior to immunizing a subject with a vaccine, wherein the vaccine comprises at least one antigen formulated in one or more adjuvants. Methods of treating and preventing disease and infection using Flt3-ligand immunization protocols are also provided. Methods of using Flt3-ligand immunization protocols for in vivo evaluation of antigens and adjuvants are also provided.

La présente invention porte sur des procédés d'utilisation du ligand Flt3 (Flt3-L) dans des protocoles d'immunisation afin d'améliorer les réponses immunes contre des antigènes de vaccin. Ces procédés consistent à administrer un ligand Flt3 avant d'immuniser un sujet avec un vaccin, le vaccin comprenant au moins un antigène formulé dans un ou plusieurs adjuvants. L'invention porte sur des procédés de traitement et de prévention de maladies et infections utilisant le ligand Flt3 dans des protocoles d'immunisation. L'invention porte aussi sur des procédés d'utilisation du ligand Flt3 dans des protocoles d'immunisation en vue d'évaluer in vivo des antigènes et des adjuvants.

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