Methods of using il-1 antagonists to treat autoinflammatory...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2568352

Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL- 1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor- associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still's Disease).

L'invention concerne des procédés permettant de traiter, inhiber ou améliorer une affection, une maladie ou un état auto-inflammatoire chez un sujet qui en a besoin, selon lesquels on administre à un sujet qui en a besoin une quantité thérapeutique d'un antagoniste de l'interleukine 1 (IL-1) afin de traiter, inhiber ou améliorer l'affection, la maladie ou l'état auto-inflammatoire. L'antagoniste de l'IL-1 est une molécule capable de lier et inhiber IL-1. Les procédés thérapeutiques de l'invention sont utilisés pour traiter un adulte ou un enfant humain souffrant du syndrome chronique infantile neurologique cutané et articulaire (CINCA), du syndrome de Muckle-Wells (SMW), de l'urticaire familial au froid (UFF), de la fièvre méditerranéenne familiale (FMF), de la fièvre périodique associée au récepteur du facteur de nécrose tumorale (TRAPS), ou de l'arthrite idiopathique juvénile avec début systémique (maladie de Still).

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