Methods of using insulin-like growth factor binding proteins

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/72 (2006.01) A61K 38/30 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160154

The invention relates to methods of using insulin-like growth factor binding proteins ("IGFBPs"), including IGFBP-1 or modified forms of IGFBP-1 as therapeutic agents. Modified forms include IGFBP-1 attached to a polymer or two IGFBP-1 molecules attached to opposite ends of a polymer. The methods involve administering IGFBPs, including IGFBP-1 or a modified form of IGFBP-1 to a patient having an IGF associated condition sufficient to cause a therapeutic effect. The invention also relates to non-phosphorylated IGFBPs useful in the methods.

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