Methods of using iron chelating compounds to reduce free...

A - Human Necessities – 61 – K

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A61K 31/44 (2006.01) A61K 31/12 (2006.01) A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/27 (2006.01) A61K 31/325 (2006.01) A61K 31/34 (2006.01)

Patent

CA 2186867

The subject invention involves a method of reducing free radical damage in mammals comprising administering to a mammal a composition comprising a safe and effective amount of a compound selected from 1-phenyl-1,2-propanedione-2-oxime, benzoylacetone, piroctone, 2-furildioxime, 2-furilmonoxime, diethyldithiocarbamic acid, deferoxamine and 1,2-dimethyl-3-hydroxy-pyrid-4-one, or a pharmaceutically acceptable salt thereof, or mixtures of the subject compounds and/or their salts.

La présente invention concerne une méthode pour diminuer les atteintes dues aux radicaux libres chez les mammifères consistant à administrer à un mammifère une quantité suffisante mais sans danger pour la santé d'un composé choisi parmi les composés suivants: 1-phényl-1,2-propanedione-2-oxime, benzoylacétone, piroctone, 2-furyldioxime, 2-furylmonoxime, acide diéthyldithiocarbamique, déféroxamine, 1,2-diméthyl-3-hydroxy-pyrid-4-one, un sel d'un de ceux-ci acceptable sur le plan pharmaceutique, les mélanges de ces composés et/ou leurs sels.

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