Methods of using mirna for detection of in vivo cell death

Details Methods of using mirna for detection of in vivo cell death Methods of using mirna for detection of in vivo cell death

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2696403

Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical factors, and the presence of specific fetal abnormalities.

L'invention concerne des procédés non invasifs de détection de la mort cellulaire in vivo en mesurant des niveaux d'ARNmi omniprésent et spécifique à un tissu. Le procédé peut être utilisé pour la détection de pathologies provoquées ou accompagnées par la mort cellulaire ainsi que pour le diagnostic d'une maladie infectieuse, d'effets cytotoxiques induits par différents facteurs chimiques ou physiques et la présence d'anomalies ftales spécifiques.

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