Methods of using quantitative lipid metabolome data

G - Physics – 01 – N

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G01N 33/92 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2459508

Described herein in various embodiments are methods for using quantitative and/or comparative lipid metabolite data, particularly for identifying and interpreting individual metabolomic profiles as indicative of metabolic status. The provided methods, for instance, allow analysis of the likelihood or progression of weight gain or weight loss, growth or wasting, obesity, diabetes, and aging in an individual based on measurements of the measurement of the quantity of one or more lipid biomarkers, profiles of such markers, or ratios of such markers.

Dans ses différents mode de réalisation, l'invention concerne des procédés d'utilisation de données quantitatives et/ou comparatives relatives à des métabolites lipidiques, en particulier pour identifier et interpréter des profils métabolomiques individuels et ainsi obtenir des indications sur l'état métabolique. Lesdits procédés permettent par exemple d'analyser la probabilité ou la progression d'une augmentation pondérale ou d'une perte pondérale, d'une croissance ou d'une atrophie, d'une obésité, d'un diabète et du vieillissement chez un individu, en fonction des mesures de la quantité d'un ou de plusieurs biomarqueurs lipidiques, des profils de tels marqueurs ou des proportions de tels marqueurs.

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