Methods of using saha and bortezomib for treating cancer

Details Methods of using saha and bortezomib for treating cancer Methods of using saha and bortezomib for treating cancer

A - Human Necessities

61

K

A61K 31/69 (2006.01) A61K 31/167 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2627129

The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Bortezomib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.

La présente invention concerne une méthode de traitement du cancer chez un sujet nécessitant un tel traitement, laquelle méthode consiste à administrer à un sujet nécessitant un tel traitement une première quantité d'un inhibiteur d'histone désacétylase (HDAC) tel que l'acide hydroxamique suberoylanilide (SAHA) ou un sel ou hydrate pharmaceutiquement acceptable de celui-ci, et une deuxième quantité d'un ou plusieurs agents anticancéreux, tels que le Bortezomib. L'inhibiteur de HDAC et l'agent anticancéreux peuvent être administrés en quantités thérapeutiquement efficaces. Selon divers aspects, l'effet de l'inhibiteur de HDAC et de l'agent anticancéreux peut être additif ou synergique.

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