A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/69 (2006.01) A61K 31/167 (2006.01) A61K 31/573 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2667348
The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor such as suberoylanilide hydroxamic acid (SAHA), or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of one or more anti-cancer agents, including Bortezomib. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.
L'invention concerne un procédé de traitement du cancer chez un patient nécessitant un tel traitement. Ce procédé consiste à administrer, à un patient nécessitant ce traitement, une première quantité d'inhibiteur de l'histone désacétylase (HDAC) notamment de l'acide suberoylanilide hydroxamique (SAHA), ou un sel ou un hydrate pharmaceutiquement acceptable de celui-ci; et une seconde quantité d'au moins un agent anticancéreux, notamment du bortezomibe. L'inhibiteur de HDAC et l'agent anticancereux peuvent être administrés pour comprendre des quantités thérapeutiquement efficaces. Dans des aspects variés de l'invention, l'effet de l'inhibiteur de HDAC et l'effet de l'agent anticancéreux peuvent s'additionner ou être synergétiques.
Gowling Lafleur Henderson Llp
University Of Maryland Baltimore
LandOfFree
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