Methods of using small molecule compounds for neuroprotection

Details Methods of using small molecule compounds for neuroprotection Methods of using small molecule compounds for neuroprotection

A - Human Necessities

61

K

A61K 31/43 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2624361

Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

L'invention concerne des procédés destinés à prévenir la neurodégénérescence et la perte neuronale par l'administration de compositions comprenant des composés de petites molécules, celle-ci ayant pour effet de prévenir la neurodégénérescence et la perte neuronale. Dans un aspect de l'invention, les procédés et compositions sont également utiles dans le traitement de maladies neurodégénératives. Les composés de petites molécules constituent une option de traitement importante en raison de leur stabilité, de leur facilité d'utilisation aussi bien à la fabrication qu'à la formulation, de leur facilité d'administration et de l'observance du traitement par les patients. Les compositions à base de composés de petites molécules comprennent des inhibiteurs de la topoisomérase II, des inhibiteurs bactériens de la transpeptidase, des antagonistes du canal calcique, des inhibiteurs de la cyclooxygénase, des inhibiteurs de la synthèse d'acide folique ou des inhibiteurs du canal sodique et des analogues fonctionnels de ceux-ci ayant un effet sur la neurodégénérescence. Les compositions de l'invention s'administrent de manière prophylactique avant le déclenchement de symptômes cliniques ou après l'apparition des symptômes cliniques d'une maladie neurodégénérative.

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