Methods of using substituted isoxazolo pyridinones as...

Details Methods of using substituted isoxazolo pyridinones as... Methods of using substituted isoxazolo pyridinones as...

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/444 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2749585

A method for treating a subject having an inflammatory or auto-immune disease with a substituted isoxazolo pyridinone. Also, a method for administering a substituted isoxazolo pyridinone to a cell to retain or increase glucocorticoid re-ceptor transrepression activity with only minimal glucocorticoid receptor transactivation activity.

Méthode de traitement d'un sujet souffrant d'une maladie inflammatoire ou auto-immune par une pyridinone isoxazolo-substituée. La présente invention concerne également une méthode d'administration d'une pyridinone isoxazolo-substituée dans une cellule pour conserver ou augmenter l'activité transrépressive des récepteurs des glucocorticoïdes avec une activité minimale de transactivation des récepteurs des glucocorticoïdes.

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