Methods of using vitamin d compounds in the treatment of...

A - Human Necessities – 61 – K

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A61K 31/59 (2006.01)

Patent

CA 2505373

Methods of treating MDS, or ameliorating a symptom thereof, are disclosed. Specific methods encompass the administration of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Other methods include intermittent administration of a high dose of one or more vitamin D compounds, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with one or more additional active agents. Such intermittent administration allows high doses of the vitamin D compounds to be administered while minimizing or eliminating hypercalcemia.

La présente invention concerne des procédés pour traiter des syndromes myélodysplasiques ou améliorer un symptôme de ceux-ci. Des procédés spécifiques consistent à administrer un ou plusieurs composés de vitamine D ou un sel, solvate, hydrate, stéréoisomère, clathrate ou promédicament de ceux-ci, acceptable d'un point de vue pharmaceutique, seuls ou associés à un ou plusieurs agents actifs supplémentaires. D'autres procédés consistent à administrer par intermittence une haute dose d'un ou de plusieurs composés de vitamine D ou d'un sel, solvate, hydrate, stéréoisomère, clathrate ou promédicament de ceux-ci, acceptable d'un point de vue pharmaceutique, seuls ou associés à un ou plusieurs agents actifs supplémentaires. Une telle administration par intermittence permet d'administrer de hautes doses de composés de vitamine D tout en minimisant ou supprimant l'apparition d'une hypercalcémie.

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